Schematic structure of the HEL–HyHEL-10 complex (PDB code: 3HFM). HEL, red; VL, green; CL, violet; VH, yellow; CH1, cyan. FR1-L(8–17), CDR1-L(24–34), FR2-L(39–44), CDR2-L(50–56), FR3-L(76–83), CDR3-L(89–97), UL1-L(138–144), UL2-L(164–173), UL3-L(198–204), FR1-H(8–17), CDR1-H(31–35), FR2-H(40–44), CDR2-H(50–65), FR3-H(83–90), CDR3-H(95–102), UL1-H(147–152), UL2-H(166–174), UL3-H(197–206).