Table 2.

NPAS2 genotypes, menopausal status, and breast cancer risk

Genotypes	Cases N (%)	Controls N (%)	Crude OR (95%CI)	P-value	Adjusted ORa (95%CI)	P-value
Ala394Thr
All women
Ala/Ala	225 (51.5)	207 (43.3)	1		1
Ala/Thr	161 (36.8)	226 (47.3)	0.65 (0.50–0.86)	0.0027	0.61 (0.46–0.81)	0.001
Thr/Thr	51 (11.7)	45 (9.4)	1.04 (0.67–1.62)	0.853	1.00 (0.63–1.57)	0.988
Premenopausal women
Ala/Ala	55 (56.3)	70 (42.4)	1		1
Ala/Thr	33 (32.0)	81 (49.1)	0.49 (0.29–0.84)	0.0087	0.44 (0.25–0.77)	0.004
Thr/Thr	12 (11.7)	14 (8.5)	1.03 (0.44–2.41)	0.937	0.93 (0.38–2.30)	0.876
Postmenopausal women
Ala/Ala	167 (50.0)	137 (43.8)	1		1
Ala/Thr	128 (38.3)	142 (46.3)	0.72 (0.52–1.01)	0.053	0.65 (0.46–0.91)	0.014
Thr/Thr	39 (11.7)	31 (9.9)	1.03 (0.61–1.74)	0.906	0.99 (0.57–1.71)	0.963
Ser471Leu
All women
Ser/Ser	292 (70.2)	328 (70.5)	1		1
Ser/Leu	110 (26.4)	129 (27.7)	0.96 (0.71–1.29)	0.778	0.98 (0.72–1.33)	0.907
Leu/Leu	14 (3.4)	8 (1.8)	1.96 (0.81–4.75)	0.127	2.22 (0.90–5.45)	0.083
Premenopausal women
Ser/Ser	64 (66.0)	112 (70.4)	1		1
Ser/Leu	29 (29.9)	43 (27.1)	1.18 (0.67–2.07)	0.563	1.27 (0.71–2.25)	0.423
Leu/Leu	4 (4.1)	4 (2.5)	1.75 (0.42–7.23)	0.434	1.97 (0.46–8.50)	0.361
Postmenopausal women
Ser/Ser	228 (71.5)	216 (70.6)	1		1
Ser/Leu	81 (25.4)	86 (28.1)	0.89 (0.62–1.27)	0.531	0.92 (0.64–1.33)	0.654
Leu/Leu	10 (3.1)	4 (1.3)	2.37 (0.73–7.66)	0.139	2.64 (0.81–8.68)	0.109

^aAdjusted for age, race, family history of breast cancer in first-degree relatives, study site, and reproductive factors including lifetime months of breast feeding, age at menarche, age at first birth, number of live birth and menopausal status. Additional adjustment for age at menopause in postmenopausal women