Table 1.

Prototypic HIV-1 Neutralizing antibodies

Target	Target site	Antibody	Reference	Potency/breadth
Virus
gp120	CD4BS	IgGb12	Burton et al. [33]	Strong/broad
		F105	Posner et al. [34]	Weak/narrow
	Glycan	2G12	Trkola et al. [21]	Moderate/broad
	V3	447−52D	Gorny et al. [47]	Strong/narrow
	CD4i	17b	Thali et al. [50]	Weak/narrow
		412D	Raja et al. [51]	Weak/narrow
		X5	Moulard et al. [52]	Weak/narrow
gp41	MPR	2F5	Muster et al. [37]	Moderate/broad
		4E10	Zwick et al. [38]	Weak/broad
		Z13	Zwick et al. [38]	Weak/narrow
	HR1	D5	Miller et al. [41]	Weak/narrow
Host protein	ICAM-1	15.2	Rizzuto et al. [81]	Weak/narrow
Cell surface	CD4	5A8/TNX-355 (hu)	Burkly et al. [93], Kuritzkes et al. [10]	Moderate/broad
	CCR5	CCR5mab004	http://www.hgsi.com	Moderate/broada
		2D7, PA14/Pro 140 (hu)	Olson et al. [11], Lee et al. [12]	Moderate/broadb
	CXCR4	12G5	Strizki et al. [113]	Moderate/broadb
		CXCR4	http://www.nwbio.com	Moderate/broadb

^aEffective against CCR5 utilizing HIV-1.

^bEffective against CXCR4 utilizing HIV-1.