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Three different conformational states of NikR (ribbon diagrams) have been structurally determined by x-ray crystallography. (a) The open form of NikR-apo from Pyrococcus horikoshii (PDB ID: 2BJ3); (b) the closed trans form of NikR with nickel (spheres) bound to the high-affinity sites from Pyrococcus horikoshii (PDB ID: 2BJ7); and (c) the closed cis form of NikR bound to the minor grooves of a palindromic DNA (surface) from Escherichia coli (PDB ID: 2HZV).
