FIGURE 2.

Correlation between Ca²⁺ redistribution and retinal cell death. (a) Changes in Ca²⁺ ion distribution during retinal ischemia were measured by TOF-SIMS, and their intensities were profiled. Ischemic retinas displayed TUNEL evidence of neuronal death, compared with the sham-operated control retina, in a time-dependent manner. (Squares indicate area of retina detected; dotted lines indicate borders of each layer of retina.) (b) Schematic representation of the relationship between Ca²⁺ ion movement and TUNEL-positive cell death in retinal ischemia. Ca²⁺ ion movement induced by ischemia within retinal layers leads to cell death.