Table 4.

Adverse Events^* Observed With EMD 273063

^*Adverse events graded 1 to 4 as per National Cancer Institute Common Toxicity Criteria, version 2.0, except as indicated.

^†Total number of patients treated at each dose level.

^‡Total number of courses administered for all patients at the indicated dose level.

^§Fever and pain graded 1 to 4 as per the University of Wisconsin Comprehensive Cancer Center Toxicity Criteria.

^||For each category of toxicity, each patient was scored based on their highest grade of toxicity for either course of treatment. The number of patients showing each grade of toxicity as their highest grade is shown for each dose level of EMD 273063.