Table 8.

CRP Monitoring^*

Course No.	Time†	No. of Patients‡	Mean CRP§	SD||	P¶
1	Pretreatment	20	2.4	4.87
	After 2 doses	16	14.9	4.95	.0005
	After 3 doses	19	9.9	3.86	.0003
	After 1 week	17	3.3	4.27	.16
	After 3 weeks	16	2.6	6.22	.46
2	Pretreatment	9	1.9	4.57
	After 2 doses	10	13.3	6.18	.009
	After 3 doses	8	9.9	3.68	.02
	After 1 week	8	2.9	3.27	.41
	After 3 weeks	6	0.7	0.52	1.00

Abbreviations: CRP, C-reactive protein; SD, standard deviation.

^*CRP levels were monitored for patients 13 through 33 (dose levels 3.2 to 7.5 mg/m²/d).

^†Samples were obtained pretreatment (day 0 or 1), after two doses (day 3), after three doses (day 4 or 5), after 1 week (day 8 or 9) and after 3 weeks (day 22 or 23).

^‡Number of patients for whom C-reactive protein data are available at each time point.

^§Mean CRP (mg/dL).

^||Standard deviation.

^¶P value when compared to day 0, 1.