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. Author manuscript; available in PMC: 2008 May 6.
Published in final edited form as: Traffic. 2008 Jan 22;9(4):510–527. doi: 10.1111/j.1600-0854.2008.00710.x

Figure 8. Model for the function and localization of dyneindynactin with respect to cytoplasmic microtubules and the cell cortex.

Figure 8

1) Dynactin localizes to cytoplasmic microtubules through its interaction with dynein. 2) Recruitment of the dynein-dynactin complex to microtubule plus ends. 3) Retention of dynein-dynactin complex at plus ends through interactions with CLIP-170/Bik1, LIS1/Pac1 and NudEL/Ndl1. 4) Dynein and dynactin are offloaded to a cortical-binding site, and dynein is activated to power microtubule sliding.