Table 1.
Chr (Mb) | Size (kb) | N SNPsb | Mean r2 | Protein (Probe set) | Original SNPc | Cheung et al. [7] p-value | Current p-valued |
5 (96) | 68 | 72 | 0.65 | LRAP (219759_at) | rs2762 | 2.0 × 10-19 | 8.0 × 0-11 |
6 (32) | 90 | 52 | 0.20 | HLA-DRB2 (209480_at) | rs6928482 | 6.5 × 10-11 | 3.8 × 10-7 |
20 (33) | 49 | 44 | 0.58 | CPNE1 (206918_s_at) | rs6060535 | 8.4 × 10-13 | 1.3 × 10-7 |
20 (36) | 25 | 16 | 0.73 | AA827892 (65588_at) | rs788350 | 3.7 × 10-15 | 1.6 × 10-5 |
21 (44) | 42 | 26 | 0.40 | CSTB (201201_at) | rs880987 | 2.5 × 10-12 | 6.5 × 10-6 |
aRegions defined as ± 5 kb surrounding original SNP and cis gene.
bBased on MAF > 0.05 in CEU HapMap release 21.
crs Identification number shown is that reported by Cheung et al. based on 57 CEU founders [7].
dCurrent p-value based on 28 CEU founders.