Table 2.

Common haplotype analysis of the S₁ candidate region

Code	S1 Haplotypea	Frequency			χ2	p
	+ + + + + + - + + + + + + + + -	Total	Case	Control
H1	2 1 1 2 1 2 1 1 1 2 1 1 2 1 1 1	0.661	0.628	0.695	9.22	0.002
H2	1 2 2 1 2 1 1 2 2 1 2 2 1 1 2 1	0.169	0.180	0.158	1.59	0.2
H3	1 2 2 1 2 1 1 2 2 1 2 2 1 2 2 1	0.101	0.120	0.082	7.32	0.007
H4	1 1 1 2 1 2 1 1 1 2 1 1 2 1 1 1	0.019	0.013	0.025	3.55	0.06
H5	1 1 2 1 2 2 2 2 2 1 2 2 1 2 2 2	0.017	0.017	0.017	0.00	1

^aSNPs from left to right: rs660936, rs674849, rs615030, rs629737, rs519596, rs660626, rs3745070, rs3745064, rs3848516, rs608017, rs608823, rs552396, rs2279096, rs1217583, rs3899444, rs4940796, '+', '-' denote a SNP with nominal association (+) or no association (-) with RA. '1', '2' denote the alleles of a SNP.