. 2007 Dec 18;1(Suppl 1):S12. doi: 10.1186/1753-6561-1-s1-s12

Table 4.

Genotype-based associations with R620W and RA sub-type (reference is major allele CC homozygote)

		PedGenie 2.1

		NARAC Study 1^a			NARAC Study 2^b			Meta-analysis			Previously published^c

RA Phenotype	Genotype	OR	95% CI	p^d	OR	95% CI	p^d	OR	95% CI	p^e	OR	95% CI	p
RF+ vs. Ctrls.	CT or TT	1.80	1.29–2.49	<0.001	2.34	1.82–3.00	<0.001	2.13	1.76–2.57	<0.001	2.36	1.76–3.16	<0.001
RF- vs. Ctrls.	CT or TT	1.40	0.87–2.27	0.20	1.08	0.71–1.65	0.77	1.20	0.87–1.65	0.31	1.17	0.6–2.31	0.64
RF+ vs. RF-	CT or TT	1.07	0.58–2.00	0.79	1.46	0.83–2.56	0.12	1.30	0.86–1.95	0.18

											Previously published^f

CCP+ vs. Ctrls.	CT or TT	1.69	1.18–2.41	0.001	2.03	1.57–2.62	<0.001	1.90	1.55–2.34	<0.001	1.49	1.23–1.79	<0.001
CCP- vs. Ctrls.	CT or TT	1.59	1.04–2.45	0.035	1.41	1.03–1.95	0.029	1.47	1.15–1.88	0.001	1.04	0.83–1.29	0.40
CCP+ vs. CCP-	CT or TT	1.05	0.61–1.80	0.93	1.16	0.83–1.60	0.32	1.12	0.84–1.50	0.47
RF or CCP+ vs. RF-/CCP-	CT or TT	1.29	0.65–2.53	0.55	1.43	0.81–2.52	0.06	1.38	0.89–2.13	0.051	1.43	1.16–1.77	<0.001

^aProblem 2 data, 446 family cases and 103 family controls in 202 affected NARAC pedigrees, 664 independent NYC controls; excludes Plenge et al. [6] samples.

^bProblem 2 data, samples in Plenge et al. [6] candidate gene file, 839 family cases in 463 pedigrees and 854 independent NYC controls.

^cBegovich et al. [3] replication sample (NARAC; 463 independent-sib cases, 926 independent controls), CLR analysis.

^dEmpirical confidence intervals and chi-square p-values, 1000 simulations; p < 0.05 in bold.

^eEmpirical confidence intervals and CMH chi-square general association test, 1000 simulations; p < 0.05 in bold.

^fPlenge et al. [6] first clinical collection, Epidemiological Investigation of RA (EIRA) Swedish cohort (2370 cases 1757 controls); allele association.