Table 4.

Power of the haplotype-trait association test using 500 case-control pairs

Common haplotypesa	Frequencyb	Model 1c (main effects of haplotypes)	Model 2c (main effects and haplotype-sex interaction effects)
			Main	Interaction
2122111112122221211221	0.06	1	0.95	0.78
1111111111311111111211	0.07	0.99	0.82	0.66
2122111112122221211121	0.11	1	0.99	0.65
1111111111311111111111 (reference haplotype)	0.39

^a Haplotypes present in at least 80 replicates of the 100 replicates (risk loci are underlined, DR locus italicized, C locus not italicized), including the alleles at the 22 loci

^b Estimated haplotype frequencies (combined sample) in the 100 replicates

^c Power is the percentage of replicates in which the main or interaction effect of the respective haplotype had an adjusted p-value of ≤ 0.05.