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. 2008 Feb 1;17(10):1418–1426. doi: 10.1093/hmg/ddn030

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

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Figure 4. — Observation of clinical symptoms and determination of lifespan in chimeras. Age at onset of symptoms was scored by a clinical assessment scale and is indicated by gray lines. Age at death (or age at onset grave symptoms requiring euthanasia) was determined and is indicated by black lines. (A) Symptoms and survival in pure mitochondrial late-onset neurodegeneration (MILON) mice (n = 25). (B) Symptoms and survival in control chimeras (n = 57). (C) Symptoms and survival in MILON chimeras (n = 63). (D) Relationship between grade of chimerism and occurrence of symptoms in MILON chimeras. (E) Relationship between grade of chimerism and occurrence of death in MILON chimeras.