Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Apr 17;131(5):1228–1240. doi: 10.1093/brain/awn053

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by Oxford University Press on behalf of the Guarantors of Brain (2008).

The online version of this article has been published under an open access model. users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commerical purposes provided that: the original authorship is properly and fully attributed; the Journal and the Guarantors of Brain are attributed as the original place of publication with the correction citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

PMC Copyright notice

Fig. 2 — Quantification and localization of degeneration-associated markers in sIBM compared to PM, DM and non-myopathic control muscle. (A) By quantitative (real-time) PCR from muscle tissue, an overexpression of the mRNA of the degenerative markers APP, desmin, NCAM, ubiquitin and αB-crystallin was observed in sIBM, PM and DM compared to non-myopathic controls. Symbols, analysis, statistics and plotting same as in Fig. 1B. (B) Fluorescent immunohistochemistry in representative muscle biopsy specimens of sIBM versus PM, DM and non-myopathic muscle, using an antibody for APP and an Alexa-594 (red)-labelled secondary antibody. Arrows point to muscle fibres that display overexpression of APP in sIBM, PM or DM (perifascicularly). Arrowheads denote an enhanced staining signal for APP in connective tissue in DM. The star indicates an upregulated expression of APP in capillaries of DM muscle. Photos taken by a CCD-camera using a conventional fluorescent microscope with a 20× objective. Scale bar represents 50 µm.

HHS Vulnerability Disclosure