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. 2008 Feb 16;36(7):2196–2207. doi: 10.1093/nar/gkn055

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Maps of the studied D4Z4 and proximal regions. (A) Cartoon (not to scale) showing the size-polymorphic D4Z4 array and p13E-11, a marker sequence. The sequence between the D4Z4 array and the telomeric hexamer repeats is about 15–25 kb. Black or gray trapezoids, essentially identical, tandem D4Z4 repeat units (3.3-kb KpnI fragments). White trapezoid, the 0.9-kb region from the start of the array to the first KpnI site in D4Z4. (B) Maps of StyI sites for chromatin DNaseI sensitivity assays. Left, StyI restriction map of the proximal border of D4Z4 including the StyI fragment spanning the 0.8-kb p13E-11 sequence through 0.3 kb at the beginning of D4Z4. Right, StyI restriction map comparing 4q35 and 10q26 D4Z4 repeat units.