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. 2008 Feb 21;36(7):2301–2310. doi: 10.1093/nar/gkn035

Figure 5.

Figure 5.

Instantaneous uncoiling velocity in the presence of TPT. Uncoiling velocities in the presence of the camptothecins. (a), (b) and (c) show histograms of instantaneous uncoiling velocities of TFO–TPT ((a), n = 51, red histogram), TFO-CPT ((b), n = 110, green histogram) and free TPT in solution (C, n = 122, blue histogram). Histograms shown in (a), (b) and (c) are all similar in their means and width. (d) histogram of the asymmetry in uncoiling velocities of the removal of negative and positive supercoils, in the presence of TFO–TPT (n = 17, red histogram). Δω is a measure for the differential in uncoiling rates: Δω = ω+ – ω–, where ω+ is the uncoiling rate of positive supercoils and ω– is the uncoiling rate of negative supercoils. (e) Histogram of the asymmetry in uncoiling velocities of the removal of negative and positive supercoils in the presence of free TPT in solution (n = 17, blue histogram). Histograms shown in (d) and (e) are similar in their means and width.