Table 2.
Mean life span of a number of unc mutant strains
| Strain | Genotype | n | Mean | Diff, % | Significance level |
|---|---|---|---|---|---|
| Experiment no. 1* | |||||
| N2 | + | 50 | 19.0 ± 0.5 | — | — |
| MQ545 | unc-24(e138) | 50 | 19.2 ± 0.6 | +1 | 0.79 |
| MQ546 | unc-24(e448) | 50 | 19.1 ± 0.4 | +1 | 0.85 |
| MQ547 | unc-24(e927) | 50 | 19.0 ± 0.5 | 0 | 0.95 |
| MQ548 | unc-24(e1172) | 50 | 19.7 ± 0.4 | +4 | 0.25 |
| Experiment no. 2 | |||||
| N2 | + | 50 | 21.7 ± 0.6 | — | — |
| MQ613 | unc-25(e265) | 50 | 22.8 ± 1.1 | +5 | 0.42 |
| MQ612 | unc-25(e591) | 50 | 22.1 ± 0.9 | +2 | 0.71 |
| MQ611 | unc-25(e891) | 50 | 22.5 ± 1.0 | +4 | 0.49 |
| MQ633 | unc-49(e382) | 50 | 23.1 ± 0.6 | +7 | 0.11 |
| MQ603 | unc-79(e1068) | 50 | 24.1 ± 0.9 | +11 | 0.03 |
| MQ604 | unc-80(e1069) | 50 | 21.6 ± 0.6 | 0 | 0.95 |
| Experiment no. 3 | |||||
| N2 | + | 50 | 19.9 ± 0.5 | — | — |
| MQ587 | unc-25(e156) | 50 | 25.1 ± 0.7 | +26 | <0.0005 |
| MQ592 | unc-26(e205) | 50 | 28.7 ± 0.6 | +44 | <0.0005 |
| MQ647 | unc-26(e345) | 34 | 29.2 ± 0.8 | +47 | <0.0005 |
| MQ574 | unc-26(e1196) | 50 | 27.3 ± 0.7 | +37 | <0.0005 |
| MQ648 | unc-26(m2) | 39 | 26.8 ± 0.7 | +35 | <0.0005 |
| MQ632 | unc-30(e596) | 50 | 18.2 ± 0.5 | −9 | 0.02 |
| Experiment no. 4 | |||||
| N2 | + | 50 | 21.6 ± 0.6 | — | — |
| MQ575 | unc-30(e191) | 50 | 20.0 ± 0.6 | −7 | 0.06 |
| MQ588 | unc-30(e318) | 50 | 16.9 ± 0.5 | −22 | <0.0005 |
| MQ578 | unc-46(e177) | 50 | 21.5 ± 1.0 | 0 | 0.96 |
| MQ579 | unc-47(e367) | 50 | 20.5 ± 0.5 | −5 | 0.16 |
| Experiment no. 5 | |||||
| N2 | + | 50 | 19.9 ± 0.7 | — | — |
| MQ636 | unc-79(e1030) | 38 | 19.1 ± 0.7 | −4 | 0.43 |
| MQ635 | unc-79(qm12) | 50 | 19.7 ± 0.5 | −1 | 0.89 |
| MQ634 | unc-79(qm14) | 50 | 21.9 ± 0.8 | +10 | 0.05 |
| MQ638 | unc-80(e1272) | 50 | 22.0 ± 0.7 | +11 | 0.03 |
| MQ608 | unc-80(qm2) | 50 | 21.2 ± 0.7 | +7 | 0.18 |
| MQ609 | unc-80(qm3) | 50 | 20.1 ± 0.6 | +1 | 0.83 |
| MQ637 | unc-80(qm9) | 50 | 19.5 ± 0.6 | −2 | 0.67 |
Columns are as described for Table 1. Before outcrossing all of the strains listed above, a number of other unc strains received from the Caenorhabditis Genetics Center or Medical Research Council (United Kingdom) also were tested. From these studies we found that mutations in the genes unc-1, -4, -6, -7, -9, and -29 do not affect life span (unpublished data).
*
unc-24 alleles have been tested four times with similar results.