Table 4.
Classification of the first series of tumors according to the number of altered APC or p53 alleles for the RER tumor subtype or the presence of TGF-βRII mutation
| Gene | Mutated/deleted alleles, n | Tumors, n
|
χ2 P | No. with mutation in TGF-βRII
|
χ2 P | ||
|---|---|---|---|---|---|---|---|
| RER+ | RER− | Yes | No | ||||
| APC | 2 | 0 | 42 | 0 | 45 | ||
| 1 | 1 | 21 | <10−4 | 2 | 22 | <10−4 | |
| 0 | 8 | 5 | 8 | 8 | |||
| p53 | 2 | 0 | 36 | 0 | 39 | ||
| 1 | 4 | 19 | 6 × 10−4 | 5 | 20 | 2 × 10−3 | |
| 0 | 9 | 17 | 9 | 22 | |||