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. 1998 Oct 27;95(22):13108–13113. doi: 10.1073/pnas.95.22.13108

Figure 1.

Figure 1

Bacterial genome subtractive DNA method. Solid lines represent AluI-digested tester and driver DNA fragments. Boxes represent outer part of PCR adaptors, which lack phosphate groups at their 5′ ends. Adaptors 1 and 2 are identical near their 5′ ends but differ near their 3′ ends. Note that after recessed 3′ ends are filled, types a, b, and c molecules having adaptor 2 are also present, but are not shown. This method is adapted from the subtraction subtractive hybridization method for studies of mRNAs in eukaryotes (18, 19).

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