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SFN and SFN-NAC inhibit HDAC activity and induce accumulation of acetylated histones in mouse colonic mucosa. Mice were treated by gavage with 10 μmol SFN, 10 μmol SFN-NAC, or vehicle alone, and colonic mucosa was isolated after 6 h. A) HDAC activities, expressed as mean ± SE, n = 3; ***P < 0.001. B) Colonic mucosa from each mouse was analyzed by immunoblot for acetylated histone H3 and acetylated histone H4; β-actin was used as a loading control.
