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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Cancer Res. 2007 Aug 1;67(15):7147–7154. doi: 10.1158/0008-5472.CAN-07-1302

Figure 6.

Figure 6

LOH of Apc increases as adenoma size increases. A, adenomas of various sizes and neighboring normal tissue were microdissected out from intestines of ApcMin/+ and Klf4+/−/ApcMin/+ mice. DNA was extracted and the extent of LOH was analyzed by semiquantitative PCR. Adenomas sizes were <1 mm (lanes 2 and 6), 1 to 3 mm (lanes 3 and 7), and >3 mm (lanes 4 and 8). Normal-appearing intestinal tissues (Nl) were also included in the analysis (lanes 1 and 5). B, densitometric analysis of the amplified Apc bands in (A).