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. 2008 May 2;105(18):6626–6631. doi: 10.1073/pnas.0711704105

Fig. 4.

Fig. 4.

Src activity in response to mechanical and/or EGF stimulation at long times. (A) Src activation is stress-magnitude dependent. n = 12 cells for stress of 17.5 Pa; 4 for 8.8 Pa; 4 for 3.5 Pa; 4 for 1.8 Pa; 3 for 0.7 Pa. It appears that Src is activated when the applied stress is >1.8 Pa. Error bars represent SEM. (B) Stress magnitude equivalent of EGF concentration. A 1.8-Pa oscillatory stress activated Src to the same extent as 0.4 ng/ml EGF (final global concentration). Stress together with EGF further increased Src activation by ≈40% at 15 min, suggesting less than additive effects. P values are 0.027, 0.036, and 0.005 between 1.8 Pa + 0.4 ng/ml and 0.4 ng/ml for 5, 10, and 15 min; P values are 0.024, 0.021, and 0.047 between 1.8 Pa + 0.4 ng/ml and 1.8 Pa for 5, 10, and 15 min. n = 4 cells for 0.5 ng/ml; 3 for 0.4 ng/ml; 3 for 0.005 ng/ml; 3 for 24.5 Pa; 7 for 1.8 Pa + 0.4 ng/ml; 6 for 1.8 Pa. Error bars represent SEM.