Fig. 1.

Thin ventricular wall and VSD in CFKO-2a embryos. (A–D) Gross examination of whole embryos at E14.5 (A and B) and E16.5 (C and D) of control (A and C) and CFKO-2a (B and D) mice. The green and blue arrows mark the edema on the dorsum and hemorrhages, respectively, of the mutant embryos. (E and F) Histopathological sections of skin from the dorsum of E14.5 embryos. Note the distinctive expansion of the s.c. tissue in CFKO-2a embryo due to edema. (G–N) Histological transverse sections through the hearts from E14.5 (G–J) and E16.5 (K–N) embryos. Note the significantly reduced thickness of the compact zone and VSD (yellow arrow) in the mutant embryos.