Fig. 4.

Analysis of cardiac defects in the surviving CFKO-2a mice. (A and B) Gross examination of the whole heart in adult control (A) and CFKO-2a (B) mice. The right ventricle in CFKO-2a mice was significantly dilated. (C and D) Histological sections show obvious dilation in CFKO-2a (D) but not the control (C) mice. (E and F) Representative M-mode echocardiogram images of hearts of 12-week-old control (E) and CFKO-2a (F) mice. The right ventricle internal diameters are marked on the right. (G) Heart weight/body weight (HW/BW) ratios (mg/g) of 12-week-old CFKO-2a mice was increased compared with the floxed FAK control and Cre control, as indicated. *, P < 0.05.