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Model for diapause regulation in the mosquito C. pipiens. Insulin signaling pathway during the nondiapausing stage, resulting in ovarian development (A), and during diapause, resulting in arrested ovarian development, fat hypertrophy, and resistance to overwintering stress (B) is shown. Arrows indicate stimulation and T-bars indicate suppression. Black and gray indicate the ON and OFF activity states of the genes, respectively.
