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. 2008 Mar 28;9(5):440–445. doi: 10.1038/embor.2008.32

Figure 1.

Figure 1

Mod(mdg4) proteins and their distribution in S2 cells. (A) Schematics of Mod(mdg4)-67.2 and its deletion derivatives: the wild-type protein (ModWT), ModΔQ, which lacks the Q-rich domain, and ModΔC, which lacks most of the Su(Hw)-binding domain. (B) Immunostained control cells; scale bar, 5 μm. (C) Transfected cells expressing Flag-tagged Mod variants specified in (A) are the upper three cells in the top row, the central one in the middle row and the right two in the bottom row; scale bar, 5 μm. All images in (B) and (C) include staining for lamin to demarcate the nuclei. (D) Crosslinking chromatin immunoprecipitation of specified chromatin regions with the Mod variants (percentage of input DNA, M±m, n=3); actin and ras coding regions are controls devoid of Su(Hw)-binding sites. Mod(mdg4), Modifier of mdg4; NLS, nuclear localization signals; Su(Hw), Suppressor of Hairy wing.