Figure 3. Impaired wound healing in p21^–/– mice in vivo.

(A) Increased cell proliferation was observed in p21^–/– mice (blue bars) compared with p21^+/+ mice (yellow bars) at the 1- and 2-week time points after arterial injury (n = 8; *P < 0.05 versus p21^+/+ at same time point) (B) Increased intima/media area ratio in p21^–/– arteries (blue bars) compared with p21^+/+ arteries (yellow bars) following wire injury (n = 8; *P < 0.05 versus p21^+/+ 1 wk, ***P < 0.001 versus p21^+/+ 2 wk). (C) Representative cross-sections of p21^+/+ (left) and p21^–/– (right) arteries stained with H&E, elastin (black), and BrdU 1 and 2 weeks after injury. Arrows indicate the internal elastic lamina. Scale bars: 40 μm.