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. 2008 May 8;118(6):2050–2061. doi: 10.1172/JCI31244

Figure 9. STAT3-dependent SDF-1 signaling pathway is impaired in the p21–/– arterial wall.

Figure 9

ChIP assays on p21+/+ and p21–/– femoral arteries using anti-STAT3 antibodies were performed before femoral wire injury (Co) and 3 and 7 days after injury. (A) Quantification of STAT3 occupancy within the SDF-1 promoter region in p21+/+ and p21–/– femoral arteries (n = 5; *P < 0.05, ***P < 0.001 versus same time point for p21+/+). As a control, chromatin from p21–/– arteries 3 days after injury was immunoprecipitated with IgG. (B) PCR amplification of the SDF-1 (–572/–372 bp) and β-actin promoters after ChIP with IgG or anti-STAT3 antibodies following vascular injury.