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. 2007 Dec 31;179(7):1523–1537. doi: 10.1083/jcb.200706181

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — Axon degeneration is regionalized in the lamina and corresponds to fan-shaped RGC loss in the retina. (A–F) Compressed Z stack images through the lamina of DBA/2J nerves with increasing levels of glaucomatous damage (neurofilaments, green; GFAP positive glia, red). Axon loss/survival is clearly regionalized to different areas of the optic nerve and not randomly distributed. (G and H) The retina and corresponding lamina region of an eye with moderate glaucoma. Discrete fan-shaped areas of RGC loss are apparent in the retina (dotted “V,” G) and appear to correspond to two regionalized areas of axon loss in the lamina (dotted boxes, H). This is consistent with localized damage to axons within the lamina leading to fan-shaped patterns of RGC loss in the retina but it was not possible to follow the region of axon loss unambiguously through the whole optic nerve head. Bars, 50 μm.