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Absence of RIIβ protein and reduction of PKA activity in the DLST of RIIβ−/− mice. (A) Immunoblot analysis of DLST homogenates from RIIβ mutant (−/−) mice and their wild-type controls (+/+) using antisera that specifically recognizes RIIβ, RIα, RIβ, or C. (B) PKA activity was measured in the striatum of wild-type controls and mutant RIIβ mice. Each bar represents PKI inhibitable activity ± SD (n = 3).
