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Energies of interhelical disulfides in chemoreceptor Tar as a function of ligand-induced conformational changes. (A) Transmembrane helix 1 (TM1)–transmembrane helix 2 (TM2) disulfides that lock the receptor in a kinase-activating (on) or kinase-inhibiting state (off). (B) TM1-TM1` disulfides that allow (allow) or block (block) signaling. Details and symbols as for Figure 5 ▶. The kink in the 36–183 curve reflects a switch in dihedral angle from one conformation to another.
