Table 3.
External prediction of membership to GPCR class using the PLS model
| Predicted Y (members/non-members) | ||||||||
| No. | Family | No. of new entries | >0.8 | 0.6–0.8 | 0.4–0.6 | <0.4 | Mispredicted | |
| 1 | Amine | 62 | 44/0 | 13/0 | 3/1 | 2 | 0 | |
| 2 | Peptide | 164 | 107/0 | 36/2 | 20/9 | 1 | 0 | |
| 3 | Glycoprotein hormone | 9 | 2/0 | 6/0 | 1/0 | 0 | 0 | |
| 4 | Opsin | 99 | 90/0 | 6/0 | 3/0 | 0 | 0 | |
| Q9YHY3, O93551, Q9WU88, | ||||||||
| 5 | Olfactory | 167 | 59/0 | 30/0 | 60/0 | 18 | 5 | Q9WU94, Q9YHY2 |
| 6 | Prostanoid | 5 | 4/0 | 1/0 | 0/0 | 0 | 0 | |
| 7 | Nucleotide like | 8 | 3/0 | 1/0 | 3/0 | 1 | 1 | O00398 |
| 8 | Cannabinoid | 3 | 2/0 | 0/0 | 1/0 | 0 | 0 | |
| 9 | Platelet activating factor | 2 | 2/0 | 0/0 | 0/0 | 0 | 0 | |
| Q9I8V4, Q9I986, Q9IA91, Q9PT72, | ||||||||
| 10 | Gonadotropin-releasing hormone | 11 | 3/0 | 1/0 | 0/0 | 7 | 7 | Q9PW33, Q9YGN8, Q9YGN9 |
| 11 | Thyrotropin-releasing hormone | 3 | 0/0 | 0/0 | 2/0 | I | 1 | O93414 |
| 12 | Melatonin | 2 | 2/0 | 0/0 | 0/0 | 0 | 0 | |
| Total | 535 | 318/0 | 94/2 | 93/10 | 30 | 14 | ||
Shown are the number of entities within ranges of conformity values (Y-values) for new entries in the GPCRDB database for members and non-members to the 12 GPCR families calculated from the model. Shown are also the number of mispredicted entries and their identifiers (see text for details).