Fig. 5.

Comparison of the amino acid compositions of intrinsic coils (gray circles) and intrinsic premolten globules (black circles) in terms of the distance of a given sequence from the border between rigid and intrinsically unstructured proteins. The distances were calculated as Δ〈H〉 = (〈H〉_boundary − 〈H〉). The mean "boundary" hydrophobicity, 〈H〉_boundary, for a given polypeptide chain with a mean net charge 〈R〉 has been calculated using equation 1. Inset shows that proteins from both subclasses occupy the same region of the charge-hydrophobicity phase space, with intrinsic coils being more dispersed.