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. 2002 Apr;11(4):974–979. doi: 10.1110/ps.4310102

Fig. 3.

Fig. 3.

Succinyl group binding pocket of DapD. (A) Stereoview of the unbiased Fo-Fo electron density map surrounding the refined coordinates corresponding to the succinamide moiety of the succinamide-CoA cofactor analog. (B) Hydrophilic interactions at the active site of the pimelate/succinyl-CoA complex. (C) Hydrophilic interactions at the active site of the L-2-aminopimelate/succinamide-CoA complex. (D) Superimposed stereoview of the two complexes, depicting the acceptor and cofactor (or analogs), surrounding water molecules, and the two residues that interact with the succinyl carboxyl group (Arg 187A, Glu 189B). The nucleophilic amino group of L-2-aminopimelate and the carbonyl carbon of the succinyl-CoA thioester are joined by a dotted line (distance 2.9 Å).