Table 1.

Closest matches to the T. maritima AP sequence from the BLAST database^a

			E. coli
Organism of AP origin	Identity to T. maritima AP	Metals	153	328	Reference
T. maritima	100%	Co(II) Mg(II)	H	W	Nelson et al. 1999
P. abyssi	44%	Unknown	H	H	Zappa et al. 2001
B. halodurans	42%	Unknown	H	W	Takami et al. 2000
Lactobacillus	40%	Unknown	H	W	AAG33874b
E. faecalis	39%	Unknown	H	W	Lee et al. 1999
TAB5	38%	Mg(II)	H	W	Rina et al. 2000
B. subtilis phoAIII	37%	Co(II)	H	W	Hulett et al. 1991
S. aureus	35%	Unknown	D	K	Kuroda et al. 2001
B. subtilis phoAIV	35%	Co(II)	H	W	Hulett et al. 1991
B. lichenformis	33%	Unknown	H	W	Kim et al. 1998a
Vibrio sp.	32%	Unknown	H	W	Asgeirsson and Andresson 2001
E. coli	28%	Zn(II) Mg(II)	D	K	Kim and Wyckoff 1991

^a Only residues that represent major changes from the E. coli AP metal-binding and active-site residues are indicated.

^b NCBI database accession number.