Table 1.

Percent similarity and identity between the predicted protein sequences of novel nAChR subunits and key C. elegans subunits

	% Identity of derived protein sequences
	DEG-3	ACR-16	ACR-8	UNC-38	ACR-17	ACR-18	ACR-19	ACR-20	ACR-21	ACR-22	ACR-23	UNC-63	UNC-29
DEG-3	∼	28	22	24	30	25	25	43	33	27	27	25	23
ACR-16	37	∼	31	37	31	28	40	34	45	23	22	37	44
ACR-8	32	41	∼	38	24	24	30	28	30	23	40	41	33
UNC-38	34	48	51	∼	26	21	32	30	39	23	22	52	39
ACR-17	41	41	36	38	∼	47	27	32	36	26	23	27	24
ACR-18	35	37	34	29	59	∼	25	30	35	25	24	26	28
ACR-19	35	49	40	41	39	32	∼	27	41	23	20	34	28
ACR-20	56	43	40	42	42	38	41	∼	34	28	49	29	29
ACR-21	46	56	43	51	47	47	54	46	∼	28	26	40	33
ACR-22	40	35	38	35	40	34	33	44	40	∼	19	25	25
ACR-23	37	35	40	34	30	31	29	57	37	31	∼	25	20
UNC-63	36	47	53	63	39	36	42	43	53	35	34	∼	41
UNC-29	34	34	47	50	34	31	40	41	46	35	29	52	∼
% Similarity of derived protein sequences

The GAP analysis program (Wisconsin Package, version 9.1, Genetics Computer Group (GCG), Madison, WI) was used to determine the percentage similarity and identity between the predicted protein sequences of novel nAChR subunits and key C. elegans subunits, DEG-3, ACR-16, ACR-8, UNC-38, and UNC-29. Default parameters were used (gap creation penalty of 12 and gap extension penalty of 4).