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. 2002 Sep;11(9):2184–2195. doi: 10.1110/ps.0209602

Fig. 1.

Fig. 1.

Degradation pathway for cumene (A), toluene (B), ethylbenzene (C), and biphenyl (D). Chemical designations are as follows: compound I, cumene; compound II, 3-isopropylcatechol; compound III, 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate (6-isopropyl-HODA); compound IV, 2-hydroxypenta-2,4-dienoate; compound V, toluene; compound VI, 2-hydroxy-6-oxohepta-2,4-dienoate (6-methyl-HODA); compound VII, ethylbenzene; compound VIII, 2-hydroxy-6-oxoocta-2,4-dienoate (6-ethyl-HODA); compound IX, biphenyl; and compound X, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (6-phenyl-HODA). Enzyme designations are as follows: A, aromatic ring dioxygenase; B, dihydrodiol dehydrogenase; C, extradiol dioxygenase; and D, meta-cleavage compound hydrolase (HODA hydrolase). Compounds III, VI, and VIII serve as good substrates for CumD, whereas compound X does not.