Table 1.
The second order rate constants (M−1s−1) and stoichiometries of inhibition (SI) for the reactions of α1-PI-LGR, α1-PI-PFR, and α1-PI-LGR-P4′E with C1s, kallikrein, factor XIIa, and activated protein C
| Rate (M−1 s−1) | SI | Rate × SI (M−1s−1) | |
| α1-PI-LGR with: | |||
| C1s | 7,350 | 1.06 | 7,790 |
| Kallikrein | 357,181 | 1.07 | 382,180 |
| Factor XIIa | 8,673 | 1.2 | 10,400 |
| Activated protein C | 2,713 | 1.3 | 3,530 |
| α1-PI-PFR with: | |||
| C1s | 236 | 2.68 | 630 |
| Kallikrein | 172,045 | 5.05 | 868,530 |
| Factor XIIa | 70 | ND | ND |
| Activated protein C | 3.5 | ND | ND |
| α1-PI-LGR-P4′E with: | |||
| C1s | 220 | 1.2 | 260 |
| Kallikrein | 214,000 | 1.2 | 256,800 |
| Factor XIIa | 1,870 | 1.8 | 3,370 |
| Activated protein C | 2,500 | 2.5 | 6,250 |
ND, not determined due to slow rate of inhibition.