Table 2.

Thermodynamics leading to the observed symmetry breaking in the mechanism of folding

	Protein L	Protein G
ΔEfold (N-terminal hairpin)	−39.3 kcal/mol	−33.6 kcal/mol
ΔEfold (C-terminal hairpin)	−31.2 kcal/mol	−28.4 kcal/mol
ΔΔEfold(N-term − C-term)	−8.1 kcal/mol	−5.2 kcal/mol
ΔEfold (total)	−64.7 kcal/mol	−58.8 kcal/mol
ΔSfold (per residue)	−0.003 kcal/mol•K	−0.003 kcal/mol•K
Length of N-terminal hairpin	21 residues	20 residues
Length of C-terminal hairpin	21 residues	14 residues
ΔΔSfold (N-term − C-term)	0 kcal/mol•K	−0.019 kcal/mol•K
-TfΔΔSfold(N-term − C-term)	0 kcal/mol	6.3 kcal/mol
ΔΔGfold(N-term − C-term)	−8.1 kcal/mol	1.1 kcal/mol