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Amino-acid sequence alignment of the LDL-A modules of the wild-type Tva, human low-density lipoprotein receptor (LDLR), and LDLR-related protein. The six conserved cysteines are boxed, and the six residues involved in calcium coordination are shaded. The arrow indicates the residue targeted for mutational analysis in this study. The residues of the Tva LDL-A module from both quail and chicken are numbered from 11 to 50 according to the mature Tva.
