Table 1.

Study flow chart.

Timepoint	Documentation	Special needs
Treatment planning and radiotherapy	Basic data (see documentation form part 1)
	Organ doses (see documentation form part 2)	1. Dose-volume-histogram for lungs, heard, liver and kidneys, if in radiation field. Therefore CT-based treatment planning is mandatory if irradiation is performed to the thorax or abdomen.
		2. Dosimetry of the thyroid gland if irradiation in head/neck area or mediastinum
		3. Dosimetry of the testes if irradiation is performed to the abdomen or to the upper part of the lower extremity
6–8 weeks after end of radiotherapy Follow-up examination	Documentation of maximal side effects that occured during or few weeks after radiotherapy according RTOG/EORTC criteria (see documentation form)	Only clinical examination
1 year after end of radiotherapy: follow-up examination	Evaluation of late sequelae according to RTOG/EORTC criteria (see documentation form)	Only clinical examination, blood values to be asked from paediatricians
2nd-10th (if feasible) year after radiotherapy follow-up examination 1×/year	Evaluation of late sequelae according to RTOG/EORTC criteria (see documentation form)	Only clinical examination, blood values to be asked from paediatricians

The documentation forms have to be sent to the RiSK study trial center in Münster: RiSK-Study trial centre, Department of Radiotherapy, University Hospital of Münster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany, Phone: +49-251-83-47384, Fax: +49-251-83-47355, E-Mail: radtox@uni-muenster.de