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. 2008 May 12;205(5):1063–1075. doi: 10.1084/jem.20071978

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© 2008 Yang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — IL-17 and IL-17F differentially regulate DSS-induced colitis. (A) Acute colitis was induced in WT, IL-17 KO, and IL-17F KO mice by oral feeding of DSS (n = 5–8 per group). Weight loss during colitis progression is shown. (B) Mice with colitis were killed on day 8, and the middle segment of the colon was fixed, sectioned, and stained with H&E. Bar, 1 mm. (C) Clinical scores are indicated based on microscopic examination of an epithelial lesion in the colon. (D) Chemokine mRNA expression was assessed in colon tissues by real-time RT-PCR. Data were expressed as the relative abundance of Actb. The experiments were repeated at least two to three times with consistent results. Results are mean values. *, P < 0.05; and **, P < 0.005 using the Student's t test.