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. 2008 May 12;205(5):1099–1108. doi: 10.1084/jem.20070850

Figure 3.

Figure 3.

No effect of sex chromosome complement for active EAE in C57BL/6 mice. (A) Active EAE was induced in castrated male XXSry and XY−Sry C57BL/6 mice with autoantigen MOG 35–55. Mean clinical disease course was no different when comparing castrated male XXSry mice to XY−Sry mice. XXSry, •, n = 6; XY−Sry, ▴, n = 6. (B) Active EAE was induced in ovariectomized female XX and XY− C57BL/6 mice with autoantigen MOG 35–55. Mean clinical disease course was also no different when comparing ovariectomized female XX versus XY− mice. XX, •, n = 6; XY−, ▴, n = 4. Data are representative of three independent experiments in males and two independent experiments in females. Graphs show mean clinical score for each group at each time point. Statistical analysis compares mean score for all days from each group. Female symbol with x overlay indicates ovariectomized female; male symbol with x overlay indicates castrated male.