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. 2008 May 12;205(5):1099–1108. doi: 10.1084/jem.20070850

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© 2008 Smith-Bouvier et al.

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Figure 5. — Effect of sex chromosome complement on Th2 cytokine levels. Ovariectomized female XX and XY⁻ SJL mice were immunized with PLP 139–151, and after 10 d, draining LNCs were stimulated with PLP 139–151 and assessed for cytokine levels in supernatants. IL-13 (top) and IL-5 (middle) were significantly increased in XY⁻ females compared with XX females. *, P < 0.05. XX, •, n = 4; XY⁻, ▴, n = 3. Ovariectomized female XX and XY⁻ SJL mice were injected with pristane, and after 10 d, splenocytes were stimulated with anti-CD3ε/anti-CD28 and cultured for cytokine production. IL-4 levels in supernatant were significantly higher in XY⁻ females as compared with XX females. *, P < 0.05. XX, •, n = 3; XY⁻, ▴, n = 3. All data are representative of at least three independent experiments. Graphs show the means and the SEM of mice in each group for each concentration. Female symbol with x overlay indicates ovariectomized female.