Table I.
Clinical features of active EAE in XX ovariectomized female SJL mice compared with XY− ovariectomized female SJL mice and XXSry castrated male SJL mice compared with XY−Sry castrated male SJL mice
| Genotype | Incidence | Mortality | Mean day of onset | Mean peak | Mean score (all days) |
|---|---|---|---|---|---|
| Experiment 1a | |||||
| XX females | 4/5 | 0/5 | 7.3 | 3.7 | 0.6b |
| XY− females | 3/5 | 0/5 | 8.3 | 2.8 | 0.2 |
| Experiment 2 | |||||
| XX females | 4/4 | 0/4 | 13 | 3.6 | 1.8b |
| XY− females | 3/3 | 0/3 | 16 | 2.3 | 0.8 |
| Experiment 3a | |||||
| XX males | 5/6 | 0/6 | 8 | 3.9b | 1.9b |
| XY− males | 4/5 | 0/5 | 8.5 | 3.1 | 0.6 |
a
These data are depicted in Fig. 1.
b
A significant difference between groups; P < 0.05.