Table II.

Static and dynamic trabecular bone parameters in long bones of control and unloaded WT (WT) and BSP^−/− mice

Genotype	WT		BSP−/−
Treatment	Control	Unloaded	Control	Unloaded	Sex
Static parametersa
SMI	2.3 ± 0.1	3.0 ± 0.1bc	1.7 ± 0.1d	2.0 ± 0.1e	Male
Tb.N (/mm)	3.6 ± 0.2	2.3 ± 0.2e	6.1 ± 0.3f	5.4 ± 0.3e
Tb.Th (μm)	51 ± 1.8	46 ± 0.8e	53 ± 1.6	48 ± 1.1e
Tb.Sp (μm)	30 ± 2.6	39 ± 3.2e	16 ± 0.8g	18 ± 1.1e
n	9	12	6	6
SMI	2.1 ± 0.1	2.4 ± 0.04e	2.2 ± 0.1	2.6 ± 0.1h	Female
Tb.N (/mm)	2.1 ± 0.1	2.4 ± 0.2	3.7 ± 0.3g	3.2 ± 0.3i
Tb.Th (μm)	67 ± 1.4	53 ± 2.0i	47±1.6f	46 ± 2.1
Tb.Sp (μm)	50 ± 3.0	44 ± 3.3	28 ± 2.5g	34 ± 4.2
n	7	8	6	8
Dynamic parametersj
N.Oc/B.Ar (/μm2)	379 ± 50	383±42	346 ± 39	354 ± 65	Male
MS/BS (%)	13.04 ± 2.69	6.14 ± 1.41e	4.93 ± 1.68k	1.18 ± 0.27h
MAR (μm/day)	2.38 ± 0.36	1.31 ± 0.10h	1.49 ± 0.19k	1.55 ± 0.88
n	9	9	7	9
N.Oc/B.Ar (/μm2)	288 ± 50	384 ± 63	277 ± 38	386 ± 37	Female
MS/BS (%)	21.51 ± 3.19	6.38 ± 1.53i	4.93 ± 1.34g	5.28 ± 1.12
MAR (μm/day)	2.98 ± 0.18	1.18 ± 0.22i	1.11 ± 0.14g	1.17 ± 0.13
n	9	10	7	7

See Materials and methods for details.

^aμCT analysis on excised tibias.

^bP < 0.0001 versus loaded control.

^cResults are the mean ± the SEM.

^dP < 0.01 versus matched WT.

^eP < 0.05 versus loaded control.

^fP < 0.0001 versus matched WT.

^gP < 0.001 versus matched WT.

^hP < 0.01 versus loaded control.

ⁱP < 0.001 versus loaded control.

^jHistomorphometry on excised femurs.

^kP < 0.05 versus matched WT.