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. 2008 May 12;205(5):1227–1242. doi: 10.1084/jem.20071460

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© 2008 Lange et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Gene expression array analysis of ATF4^+/+ and ATF4^−/− neurons before and after treatment with HCA. (A) Heatmap with cluster dendrogram of the differentially expressed genes (log2 fold change vs. control) at a false discovery rate of 5%. Unsupervised clustering groups samples by genotype and by treatment. Genes are in rows and samples are in columns. Column color coding is as follows: red, ATF4^−/− versus ATF4^+/+ untreated neurons; blue, HCA-treated ATF4^−/− versus untreated ATF4^−/− neurons; and green, HCA-treated ATF4^+/+ versus untreated ATF4^+/+ neurons. (B) The number of genes that are up- (red) and down-regulated (green). Shown are three different contrasts: ATF4^−/− versus ATF4^+/+ untreated neurons, HCA-treated ATF4^+/+ versus untreated ATF4^+/+ neurons, and HCA-treated ATF4^−/− versus untreated ATF4^−/− neurons. The complete list of differentially expressed genes is available in Table S3 (available at http://www.jem.org/cgi/content/full/jem.20071460/DC1). ANOVA FDR, analysis of variance false discovery rate; C, control.