Figure 4.
Effect of amplification. Bifurcation diagrams for increasing silencing strength. In this case we varied Dicer cleavage rates. On the left, Dicer cleaves dsRNA; on the right Dicer cleaves dsRNA and plus- and minus-strand ssRNA. In the case of Dicer cleaving plus- and minus-strand RNA cd = cs. Solid black lines show the number of plus-strand RNA 300 hours post infection, violet lines show the number of virions, and cyan lines the total number of siRNAs. Dashed lines show the behavior when amplification yields four siRNAs per amplified transcript. For clarity the lines representing siRNAs have been omitted in figure C-H.