Table 1.

Parameters used in the model with their default value and the studied range. #mol is number of molecules.

Par.	Meaning	Value units	Studied range	Reference
r	maximum translation rate * #ribosomes	15*5000 #mol hr-1	30,000 – 750,000	[38,39]
o	max rate of complex formation ssRNA	1 hr-1	0.1 – 5
o d	max rate of complex formation dsRNA	100 hr-1	0 – 1000
f	ratio of binding plus or minus RNA	0.9 -	0 – 1
h	dsRNA-RDR splitting rate	10 hr-1	1 – 1,000
v	max virion production rate	500 #mol hr-1	0 – 50,000
D i	number of Dicer molecules	500 #mol	0 – 5,000
c d	max Dicer cleavage rate for dsRNA	3 #mol hr-1	0 – 20
c s	max Dicer cleavage rate for ssRNA	3 #mol hr-1	0 – 20
b1	rate of RISC activation	0.005 #mol -1 hr-1	0 – 1
b2	RISC target cleavage rate	20 #mol -1 hr-1	0 – 1,000	[8]
i	translation of RISC	100 #mol hr-1	0 – 1,000
a	amplification (au, ap and ag)	100 #mol hr-1	0 – 400
d r	decay RDR and RISC	0.1 hr-1	0 – 0.5
d	decay viral ssRNA	0.5 hr-1	0 – 2
d si	decay siRNA	2 hr-1	0 – 5	[40]
k v	saturation of virion production	10,000 #mol	1 – 100,000
k d	saturation of Dicer cleavage	10,000 #mol	1 – 100,000
k t	saturation constant for translation	1,000 #mol	1 – 10,000
k ri	saturation of RISC cleavage	1,000 #mol	1 – 10,000
k r	saturation of complex formation	1,000 #mol	1 – 10,000
k a	saturation amplification	1000 #mol	1 – 10,000