Figure 5.

(A) Kinetics of NPe6 accumulation in tumor and normal vessels as a function of time after i.v. administration. The data points are an average of at least 12 independent measurements, and the error bars represent SDs. The data points marked with an asterisk indicate that the NPe6 levels for the normal and tumor tissues at the corresponding time point were statistically significant with a P value < .05. (B) Representative map of temporal kinetics of extravascular NPe6 distribution as a function of distance from CD31-labeled vessels. (C) The 180 minutes image from Figure 2 with the ROI (shaded in white) superimposed on the region where the data for the representative map in (B) was obtained. The dimensions of the ROI are 20 µm x 105 µm.